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UNKNOWNNCT06421116

Validation of a Preclinical Model Based on Patient-derived Organoids for the Study of the Gut-joint Axis in Spondyloarthritis

This project aims to develop and validate a model of human organoids derived from patients with Spondyloarthritis, focusing on synovial and intestinal tissues as targets of the gut-joint axis. The tis...

Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS•1 locations•View source on ClinicalTrials.gov

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Contacts

Maria Antonietta D'Agostino, Professor

CONTACT

+390630157807 mariaantoniettadagostino@policlinicogemelli.it

Gerlando Natalello, Dr

CONTACT

+390630157807 gerlando.natalello1@guest.policlinicogemelli.it

Sponsors

Lead Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•More than 18 years of age;
•Ability to understand and sign an informed consent form;
•Clinical indication for intestinal and/or synovial biopsy;
•Only for SpA patients group: meeting ASAS classification criteria.

Exclusion Criteria

•Actively treated cancer;
•Severe comorbidities that, in the investigator\'s opinion, may affect the quality of samples for planned experimental applications;
•Only for patients undergoing ileal-colic biopsy: history of colorectal cancer disease, celiac disease;
•Only for patients undergoing a synovial biopsy: septic arthritis.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 20, 2024Terms

Trial snapshot

StatusUNKNOWN

Phase—

Enrollment60

Start dateMar 2024

Last updatedMay 20, 2024

Condition

Spondyloarthritis Inflammatory Bowel Diseases

Locations shown

Fondazione Policlinico Universitario A. Gemelli IRCCS

Rome, RM

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 20, 2024Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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