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A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of 3 Active Dose Regimens of MORF-057 in Adults With Moderately to Severely Active Crohn's Disease (GARNET)
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 3 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's disease (CD).
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of induction therapy with 3 active dose regimens of MORF-057 versus matching placebo in adult study participants with moderately to severely active CD. After completion of the 14-week Induction Period, all participants will receive open-label MORF-057 during the 38-week Maintenance Period. All participants who complete the full 52-week Treatment Period will also have the opportunity to continue treatment in a 52-week Long-Term Extension.
Age
18 - 85 years
Sex
ALL
Healthy Volunteers
No
Gastro Care Institute
Lancaster, California, United States
Infinity Clinical Research
San Diego, California, United States
Peak Gastroenterology Associates - Colorado Springs
Colorado Springs, Colorado, United States
Clinical Research of Osceola
Kissimmee, Florida, United States
Bioresearch Partner-Kendale Lakes
Miami, Florida, United States
Atlanta Gastroenterology Specialists, PC
Atlanta, Georgia, United States
Atlanta Gastroenterology Associates (Part of United Digestive)
Atlanta, Georgia, United States
Cross Creek Medical Clinic
Fayetteville, North Carolina, United States
Peters Medical Research
High Point, North Carolina, United States
Wake Research Associates
Raleigh, North Carolina, United States
Start Date
July 18, 2024
Primary Completion Date
September 1, 2028
Completion Date
June 1, 2030
Last Updated
March 20, 2026
385
ESTIMATED participants
Placebo
DRUG
MORF-057
DRUG
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
1-317-615-4559LillyTrials@Lilly.comPhysicians interested in becoming principal investigators please contact
CONTACT
clinical_inquiry_hub@lilly.comLead Sponsor
Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
NCT07184931
NCT06918808
NCT07385131
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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