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RECRUITINGNANCT06408077

Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges

Hyponatremia is the most common electrolyte disorder of all and can be observed in more than 30% of all patients in hospitals. Osmotic homeostasis of body fluids is essential for survival of all livin...

Lead sponsor: University of Cologne•1 locations•View source on ClinicalTrials.gov

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Contacts

Volker Burst, MD

CONTACT

+49 221 478 86285 volker.burst@uk-koeln.de

Sadrija Cukoski, MD

CONTACT

sadrija.cukoski@uk-koeln.de

Sponsors

Lead Sponsor

University of Cologne

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Adult patients ≥18 years
•Requirement of renal replacement therapy due to surgical (i.e., nephrectomy) or non-surgical (chronic kidney disease) reason
•Stable hemodialysis treatment for at least 3 months
•Urine output \<100ml in 24 hours
•Glucose-corrected plasma sodium between 135 mmol/l and 145 mmol/l
•Plasma potassium between 3.5 mmol/l and 5 mmol/l
•Written informed consent

Exclusion Criteria

•Peritoneal dialysis patients
•Signs of volume expansion or contraction
•Congestive heart failure (NYHA ≥2)
•acute illness (infection, congestive heart failure, liver cirrhosis, etc.) requiring hospital admission
•Uncontrolled arterial hypertension
•Hemoglobin ≤8g/dL
•Alcohol abuse
•Malnutrition
•Persons, who are in a dependency/employment relationship with the investigators
•Accommodation in an institution by judicial or administrative order

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 17, 2025Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment60

Start dateJul 2023

Last updatedSep 17, 2025

Condition

Locations shown

Department II of Internal Medicine,University of Cologne

Cologne

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 17, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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