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COMPLETEDNCT04227301

Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients

In this study, the possible role of serum sodium concentration and its changes on bone markers in hospitalized, hyponatremic patients is determined. Therefore, it is investigated whether in hospitaliz...

Lead sponsor: University Hospital, Basel, Switzerland•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University Hospital, Basel, Switzerland

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Adult hospitalized patients with non-hypertonic hyponatremia: serum sodium \< 130 mmol/l, serum osmolality \< 300 milliosmol /kg
•age 18 to 99-year-old
•Informed consent as documented by signature

Exclusion Criteria

•Severe symptomatic hyponatremia in need of intensive care treatment
•Hypertonic hyponatremia with serum osmolality \> 300 mOsm/kg
•End of life care (palliative treatment)
•End stage kidney disease (dialysis)
•Acute liver failure
•Wernicke encephalopathy
•Hepatic encephalopathy during last 2 months
•Hepato-renal syndrome
•Any bone disease requiring treatment in the last three years
•History of fragility fractures
•Pre-menopausal women
•Hypogonadism (diagnosed before hospitalization)
•Hyperthyroidism
•Steroid therapy

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 29, 2025Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment52

Start dateFeb 2020

Last updatedMay 29, 2025

Condition

Locations shown

Endocrinology, Diabetes and Metabolism, University Hospital Basel

Basel

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 29, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions