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Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following DRF Fixation | Clinical Trials | Clareo Health

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Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following DRF Fixation

The Effect of Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - the TRADR Study

NCT06384456•University Health Network, Toronto

View on ClinicalTrials.gov

Summary

The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;
•Aged 18 or older;
•Provision of informed consent;
•Cognitive ability and English-language skills required to complete outcome measures.

Exclusion Criteria

•Revision surgery or any additional operative management of ipsilateral wrist injury
•Distal radius fracture treated with a dorsal approach
•Known history of lymphedema or lymph node dissection in the operative extremity
•Known chronic pain conditions, fibromyalgia, or polymyalgia rheumatic
•Current user of opioids and/or on chronic opioids use
•Known allergic reaction to TXA
•Anticoagulant use not stopped in time for surgery as per thrombosis Canada guidelines (i.e. warfarin, acetylsalicylic acid, direct oral anticoagulants, etc.)
•Previous thrombotic stroke or thromboembolic disorders (i.e. known previous DVT, PE, or clotting disorders)
•Current pregnancy or breastfeeding
•Previous neurologic injury causing paralysis of affected shoulder/arm
+1 more criteria

Locations (1)

Toronto Western Hospital

Toronto, Ontario, Canada

Key Dates

Start Date

March 1, 2025

Primary Completion Date

June 1, 2026

Completion Date

September 1, 2026

Last Updated

March 28, 2025

Enrollment

ESTIMATED participants

Conditions

Distal Radius Fractures

Interventions

Topical TRanexamic Acid

DRUG

Placebo

DRUG

Contacts

Ryan Paul

CONTACT

416-603-5839 jhanna.bermudez@uhn.ca

Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.

NCT06678438

Distal Radius FracturesFracture Dislocation+3 more

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RECRUITINGNA

Mechanical Modalities vs. Standard Care for Edema and Pain Management After DRF Fixation

NCT06913920

Distal Radius Fractures

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 28, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following DRF Fixation

Inclusion Criteria

Exclusion Criteria

Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.

Mechanical Modalities vs. Standard Care for Edema and Pain Management After DRF Fixation

Prednisone for CRPS in Distal Radius Fracture

Opioid-Free Pain Treatment in Trauma Patients

Is Sensorimotor Training Effective Following a Distal Radius Fracture?

Hematoma Block Versus Bier Block for Closed Fracture Reduction