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A Pragmatic Diagnostic Accuracy Study of a Triple Diagnostic Approach and Exploratory Biomarkers in Adult Asthma Diagnosis
The goal of this trial is to learn if the addition of oscillometry with reversibility testing increases diagnostic accuracy in adult asthma diagnosis, when added to current standard of care tests: spirometry with reversibility testing and Fractional Exhaled Nitric Oxide (FeNO). The main question it aims to answer is: \- Does oscillometry with reversibility testing increase diagnostic accuracy in detection of asthma in adults when added to spirometry with reversibility and FeNO? Researchers will evaluate the diagnostic accuracy of this approach with the reference standard, which is a clinically adjudicated diagnosis of asthma by two respiratory clinicians based on history and investigation results. Participants will * Undergo oscillometry testing alongside their routine asthma investigations within their scheduled clinic visit * Optionally participate in our sub-studies on new breath and nasal swab tests for asthma * Optionally participate in our qualitative substudy on patients views and attitudes to asthma testing and oscillometry
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Imperial College Healthcare NHS Trust
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Start Date
June 1, 2024
Primary Completion Date
December 1, 2025
Completion Date
July 1, 2026
Last Updated
April 25, 2024
225
ESTIMATED participants
Oscillometry with reversibility testing
DIAGNOSTIC_TEST
Breath volatile testing
DIAGNOSTIC_TEST
Nasal eosinophil peroxidase
DIAGNOSTIC_TEST
Handheld capnometry
DIAGNOSTIC_TEST
Lead Sponsor
Imperial College London
Collaborators
NCT07219173
NCT02327897
NCT07486401
Data Source & Attribution
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