Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

Exclusion Criteria

• •1. Positive urine drug screen prior to surgery
• •2. History of substance abuse in the past year-by self report
• •3. Patient with ongoing daily narcotic use at the time of surgery-by self report
• •4. Inability to understand informed consent or read English/Spanish
• •5. Pregnant or lactating patients
• •6. Prisoners
• •7. Patients with renal or hepatic failure
• •8. Bupivacaine use within 96 hours of operation
• •9. Patient intolerant of opiates, nonsteroidal anti-inflammatory drug s, acetaminophen, or Zynrelef and Exparel. Subjects in all cohorts must not have any contraindications to any of the protocol-specified drugs
• •10. Patient with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients