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Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity-Associated Diseases
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Participants with obesity will complete meetings with study team members for a weight loss intervention to achieve a 10% body weight loss.
Age
18 - 70 years
Sex
ALL
Healthy Volunteers
Yes
University of Missouri School of Medicine
Columbia, Missouri, United States
Start Date
August 1, 2024
Primary Completion Date
March 1, 2028
Completion Date
March 1, 2028
Last Updated
July 18, 2025
60
ESTIMATED participants
Dietary consultation weight loss intervention
OTHER
Lead Sponsor
Bettina Mittendorfer
Collaborators
NCT01143454
NCT07472881
Data Source & Attribution
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Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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