Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

Exclusion Criteria

• •Current diagnosis or history of diabetes mellitus.
• •Started medications within 3 months prior to Screening that may cause significant weight gain, including, but not limited to, tricyclic antidepressants, atypical antipsychotics, and mood stabilizers.
• •Unstable weight defined as self-reported change in body weight exceeding 5% within 3 months prior to Screening.
• •Family or personal history of multiple endocrine neoplasia Type 2 or medullary thyroid cancer.
• •Uncontrolled hypertension or unstable cardiovascular disease.
• •History of chronic or acute pancreatitis.
• •Known clinically significant gastric-emptying abnormality or chronic treatment with medications that directly affect gastrointestinal motility.
• •History of suicide attempt.
• •History of significant active or unstable Major Depressive Disorder (MDD) or other severe psychiatric disorder.
• •Received treatment with semaglutide, tirzepatide, GLP-1 receptor agonist, GLP-1/glucose-dependent insulinotropic polypeptide (GIP), or glucagon receptor agonist within 3 months prior to Screening.