Inflammatory Control of Antidepressant Efficacy: a Pharmaco-epigenetic Approach

Exclusion Criteria

• •History of bipolar disorder, schizophrenia, schizoaffective disorder, psychosis not otherwise specified; anorexia or bulimia nervosa;
• •Taking following medications: antipsychotics, anticonvulsants, mood stabilizers; stimulants
• •Active infection requiring antibiotics therapy;
• •Immunosuppressed patient
• •Other chronic diseases
• •Signs of active infection requiring treatment
• •Use of anti-inflammatory medication on a regular basis for a chronic inflammatory/autoimmune Disorder.
• •Forbidden treatment: corticosteroids, Non Steroidal Anti-inflammatory Drugs, immunosuppressant IV-Ig based treatment
• •Ongoing fever, infection treated by antibiotics or uncontrolled diabetes type I or II;
• •Existing cancer or history of cancer in the last 5 years (except skin epidermoid cancer or in-situ cervix cancer);
• •Known HIV infection or clinically manifest Acquired Immune Deficiency Syndrome (AIDS),
• •Parkinson's or Alzheimer's disease, or any other serious condition likely to interfere e with the conduct of the trial;
• •Abuse of drugs or alcohol in the past 6 months