The ESG Integrity Study: Effect of Proton Pump Inhibitors on the Structural Integrity of Endoscopic Sleeve Gastroplasty

Exclusion Criteria

• •Active gastric gastro-duodenal during the last 6 months
• •Helicobacter pylori infection.
• •Organic or motility disorder of the stomach and / or esophagus
• •Anticoagulant treatment
• •Previous bariatric surgery or any other type of surgery of the esophagus, stomach and duodenum
• •Ongoing or active malignancy during the last 5 years.
• •Myocardial infarction during the past 6 months or/and heart failure class III or IV according to the New York Heart association's classification.
• •Drug or alcohol abuse
• •Bulimic or binge eating pattern
• •Continuous glucocorticoid or anti-inflammatory treatment
• •Uncontrolled thyroid disease.
• •Pregnancy, breastfeeding
• •Psychiatric or cooperative problems or low compliance that is a contraindication from participating in the study.
• •Hiatal hernia ≥ 5 cm
• •Known allergy or hypersensitivity to the active substance or any of the other excipients
• •Liver cirrhosis of any Child-Phugh stage or MELD\> 15
• •Chronic Severe Renal Insufficiency (eGFR \< 30 ml/min/1.73 m2 based on CKD-EPI equation)
• •Currently participating in other study, or previously participated in an experimental drugs trial within 30 days before or 5 half-life of the drug administered
• •Any health issue that might put the patient at risk if the treatment is performed, judged by the investigator.