Finding studies
Finding studies
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Piotr Dobrowolski, Professor
CONTACT
Aleksander Prejbisz, Professor
CONTACT
Lead
National Institute of Cardiology, Warsaw, Poland
Purpose: To evaluate best medical management to achieve the ESC/ESH 2018 BP goals of 120-129 / 70-79 mmHg in HT patients aged \< 65 y not controlled on 3 or more antihypertensive drugs. Study design: Phase A (Active screening) (n = 2500) 7 days Confirmation of the true ineffectiveness of antihypertensive therapy based on 3 or more antihypertensive drugs (single or dual drug preparations) using ABPM and home BP measurements. Phase B (Open-label, non-randomized) (n = 1250) 12 weeks Replacement of ineffective antihypertensive treatment based on 3 or more antihypertensive drugs (single or dual drug preparations) with a triple single pill combination (SPC) based on optimally combined antihypertensive drugs: perindopril + indapamide + amlodipine (P+I+A) or olmesartan + hydrocholothiazide + amlodipine (O+H+A). Phase C (Double blind, randomized, parallel-group) (n = 480) 24 weeks Comparison of antihypertensive efficacy and tolerability profile: * spironolactone * eplerenone * torasemide attached as an antihypertensive drug of 4th choice.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted