Neural Circuit Effects of Ketamine in Depression

Exclusion Criteria

• •MDD Group
• •Current or history of schizophrenia or other psychotic disorder/episode, bipolar disorder, neurodevelopmental disorder, or neurocognitive disorder;
• •Current major depressive disorder with psychotic features;
• •Substance use disorder within the past 2 years\*;
• •Lifetime history of ketamine use disorder;
• •Antidepressant medication within 2 weeks of Baseline (4 weeks for fluoxetine);
• •Severe current illness as reflected by a CGI score \>5;
• •Any unstable medical illnesses including hepatic, renal, gastroenterologic, respiratory, cardiovascular (including ischemic heart disease); endocrinologic, neurologic (including history of severe head injury), immunologic, or hematologic disease;
• •Clinically significant abnormalities of laboratories, physical examination, or ECG;
• •Positive urine toxicology screen for drugs of abuse at the time of screening, except cannabis;
• •Women who plan to become pregnant, are pregnant or are breast-feeding (because the medical risk of using ketamine during pregnancy and breast-feeding is unknown);
• •Active suicidal intent or plan; CSSRS score \>2;
• •Any contraindications to MRI, including claustrophobia, any trauma or surgery which may have left magnetic material in the body, magnetic implants or pacemakers, and inability to lie still for 1 hour or more;
• •Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the participant or the quality of the data.
• •HC Group
• •Current or history of any psychiatric, neurodevelopmental disorder, or neurocognitive disorder;
• •Substance use disorder within the past 2 years\*;
• •Any unstable medical illnesses including hepatic, renal, gastroenterologic, respiratory, cardiovascular (including ischemic heart disease); endocrinologic, neurologic (including history of severe head injury), immunologic, or hematologic disease;
• •Clinically significant abnormalities of laboratories or physical examination;
• •Positive urine toxicology screen for drugs of abuse at the time of screening, except cannabis;
• •Current pregnancy;
• •Women who are breast feeding;
• •Active suicidal intent or plan; CSSRS score \>2;
• •Any contraindications to MRI, including claustrophobia, any trauma or surgery which may have left magnetic material in the body, magnetic implants or pacemakers, and inability to lie still for 1 hour or more.