Margaret MacMillan

CONTACT

Lead Sponsor

Masonic Cancer Center, University of Minnesota

Age

0 - 60 years

Sex

ALL

Healthy Volunteers

No

•Histological confirmation of hematological malignancies
•Acute leukemias
•Acute Myeloid Leukemia (AML) and related precursor neoplasms
•Favorable risk AML is defined as having one of the following:
•Acute lymphoblastic leukemia (ALL)/lymphoma
•Myelodysplasia (MDS) IPSS INT-2 or High Risk (i.e. RAEB, RAEBt) or Refractory Anemia with severe pancytopenia, transfusion dependence, or high risk cytogenetics or molecular features.
•Age 60 years of age or younger at the time of consent
•Karnofsky performance status ≥ 70% or Lansky play score 50% for ≤16 years of age.
•Adequate organ function

•Pregnant or breastfeeding.
•Active uncontrolled infection within 1 week of starting preparative therapy
•Known seropositive for HIV or known active Hepatitis B or C infection with detectable viral load by PCR.
•Any prior autologous or allogeneic transplant
•CML blast crisis
•Active central nervous system malignancy