Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics

Exclusion Criteria

• •Inability to undergo MRI (e.g., metal in body, claustrophobia, orthodontia) and/or EEG.
• •Active suicidality Previous diagnosis of psychosis, cognitive disability, or structural brain disease that in the investigator opinion would impede participation.
• •History of seizure disorder
• •Active substance abuse or dependence.
• •Presence of another psychiatric or medical condition requiring immediate treatment and/or for which delay of treatment to focus on tics would be clinically inappropriate. Participants will not be excluded for comorbidities that commonly occur with TS (e.g., ADHD, OCD, anxiety) provided that this criterion is met, as only 10-15% of patients with TS have no comorbidities.
• •Concurrent psychotherapy focused on tics and/or involving procedures that overlap with CBIT (e.g., habit reversal therapy, exposure therapy targeting repetitive behaviors).
• •Psychotropic medication changes in the past 6 weeks and/or plans to change medication during the study period through post-treatment assessment.
• •≥ 4 previous sessions of CBIT.