Ashwagandha Pharmacokinetics Study in Older Adults

Exclusion Criteria

• •1. Current smoking, alcohol, or substance abuse according to DSM-V criteria
• •2. Participants who are currently pregnant, actively trying to conceive a child, or planning to within three months of study completion
• •3. Severe aversion to venipuncture
• •4. Donation of blood within 90 days of screening
• •5. Participation in drug research study within 90 days of screening
• •6. Serious health condition (i.e., illness, injury, impairment, or physical or mental condition which requires a) overnight hospitalization or b) continuing treatment that may cause episodic periods of incapacity of more than 3 consecutive days) within 30 days of screening
• •7. Allergy to nightshade plants (Solanaceae family)
• •8. Abnormal labs indicating symptomatic and untreated urinary tract infection
• •9. History of prostate cancer
• •10. History of kidney transplant
• •11. Cancer within the last five years, with the exception of non-metastatic skin cancers
• •12. Comorbid conditions requiring medication such as diabetes, kidney failure, liver failure, hepatitis, blood disorders, hypotension, thyroid disease, respiratory disorders, or cardiovascular disease
• •13. Presence of sleep apnea, moderate to severe restless leg syndrome, major circadian rhythm changes, or narcolepsy
• •14. Significant disease of the Central Nervous System (CNS) such as brain tumor, seizure disorder, subdural hematoma, cranial arteritis, or clinically significant stroke
• •15. Diagnosis of major depression, schizophrenia, bipolar disorder, or other major psychiatric disorder as defined by DSM-V criteria
• •16. Diseases associated with dementia such as Alzheimer's disease, vascular dementia, normal pressure hydrocephalus or Parkinson's disease