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Cognitive Training to Enhance Brain-to-brain Concordance During Acupuncture
This study will evaluate the impact of a novel non-pharmacological multimodal therapy, a type of approach known to improve pain outcomes and recommended by the Institute of Medicine report for chronic pain management. This study design will also allow the investigators to evaluate a neural model supporting therapeutic alliance for pain outcomes for fibromyalgia.
The patient-clinician interaction is central to most therapies and is supported by key interpersonal mechanisms of action such as clinician empathy, therapeutic alliance, and trust. However, the neural underpinnings of this effect are mostly unknown. The investigators' recently published study applied functional MRI (fMRI) hyperscanning (i.e. simultaneously neuroimaging chronic pain patients and clinicians in synchronized MRI scanners) demonstrated that brain-to-brain concordance in the temporoparietal junction (TPJ) is up-regulated following a clinical interaction and associated with patient analgesia. Fibromyalgia is a chronic pain disorder in great need of novel therapies. This study will evaluate the impact of a novel multimodal therapy, a type of approach known to improve pain outcomes and recommended by the Institute of Medicine report for chronic pain management. The study design will also allow the investigators to evaluate a neural model supporting therapeutic alliance for pain outcomes for fibromyalgia wherein training and acupuncture will synergistically target a critical therapeutic pathway - i.e., patient-provider alliance, instantiated by TPJ concordance.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
Massachusetts General Hospital
Charlestown, Massachusetts, United States
Spaulding Rehabilitation Hospital
Charlestown, Massachusetts, United States
Brigham and Women's Hospital
Chestnut Hill, Massachusetts, United States
Start Date
February 16, 2024
Primary Completion Date
June 30, 2027
Completion Date
June 30, 2027
Last Updated
October 24, 2025
100
ESTIMATED participants
Electroacupuncture
OTHER
Cognitive Training
BEHAVIORAL
Education Training
BEHAVIORAL
Lead Sponsor
Spaulding Rehabilitation Hospital
Collaborators
NCT05901259
NCT03759522
Data Source & Attribution
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