Women pregnant or breastfeeding

Suicidal (PHQ-9 question 9 score \>2) or Severely Depressed (PHQ-9 score \>20)

Uncontrolled hypertension (≥180 systolic or ≥100 diastolic blood pressure)

Lower limb orthopedic limitations (e.g. amputations, arthritis)

Resting heart rate \>90/min

Known atherosclerotic or non-atherosclerotic peripheral artery disease.

Exercise intolerance due to other known medical condition(s) which may make it unsafe for the patients to participate in.

Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study