Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung

In this observational study, we will be enrolling patients with diagnosed or suspected airways disease who are over 18 years old, as well as age matched healthy volunteers with no significant illness. Participants will be asked if they consent to enter the study, invited at clinically relevant time points (treatment change, disease exacerbation etc.) and to optional bronchoscopy visits. It is expected that participants will be seen yearly with any additional exacerbation/treatment visits also recorded. Research visits will occur at King's College London and the Guys and St Thomas' NHS Foundation Trust (GSTFT), with all bronchoscopy visits occurring within GSTFT 1. Disease specific questionnaires. 2. Lung function tests including spirometry or oscillometry (if not performed previously within 6 months) 3. Sputum collection 4. Nasal sampling including nasosorption, nasal brushing, nasal lavage, or nasopharyngeal swabs 5. Exhaled breath 6. Blood samples (\<6 tablespoons) Optional 7. Bronchoscopy involving a flexible fibreoptic camera passed into the lungs to collect bronchoalveolar lavage, bronchosorption, bronchial brushings and bronchial biopsies. 8. To repeat these procedures at later time - expected once per year or at times of clinically relevant changes