A Study to Investigate the Safety and Tolerability of CAN10 Antibody in Healthy Subjects and in Subjects With Plaque Psoriasis.

Exclusion Criteria

• •History or presence of:
• •1. Severe allergy/hypersensitivity (subjects with mild pollen allergy can be included).
• •2. Significant kidney, liver, or urologic disease.
• •3. Clinically significant psychiatric disorders
• •4. Tuberculosis (TB) infection or positive QuantiFERON TB Gold test
• •5. Any other clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject's ability to participate in the study.
• •Clinically significant illness, medical/surgical procedure, or trauma within 4 weeks before the first dose of study drug.
• •Ongoing opportunistic or systemic infections
• •A positive test result for hepatitis B surface antigen, hepatitis C virus antibody, or human immunodeficiency virus antigen or antibodies at screening.
• •Additionally for subjects with plaque psoriasis only:
• •Psoriasis other than a plaque variant.
• •Any sign of infection of any of the psoriatic lesions.
• •Use of any of the following treatments within the indicated washout period before the first dose of study drug:
• •1. 12 weeks or 5 half-lives (whichever is longer) for biologic agents known or expected to impact the course of psoriasis or its assessments.
• •2. 12 weeks for oral retinoids
• •3. 8 weeks for cyclosporin, interferon, methotrexate, other systemic immunosuppressive or immunomodulating agents, or psoralen plus ultraviolet A (UVA)
• •4. 2 weeks for immunizations or drugs known to possibly worsen psoriasis, unless on a stable dose for \>12 weeks
• •5. 1 week for topical treatments: corticosteroids, immunomodulators, anthralin (dithranol), Vitamin D derivatives, retinoids, or coal tar (used on the body)