The Relationship Between Fetal Membrane Thickness and Fetal Chromosomal Aneuploidies

Inclusion Criteria

• •1. Singleton pregnant women between 18-24 weeks of gestation.
• •2. Participants with high-risk indications for prenatal fetal chromosomal abnormalities, including:
• •* Nuchal translucency (NT) ≥ 3 mm.
• •* High-risk results from non-invasive prenatal testing (NIPT) using cell-free fetal DNA from peripheral maternal blood.
• •* Ultrasound-detected fetal abnormalities.
• •* Other indicators include adverse birth histories, parental chromosomal abnormalities, familial diseases, and a history of thyroid cancer post-surgery.
• •3. Gestational age and estimated due date were confirmed by the first day of the last menstrual period and adjusted using fetal crown-rump length measured during the first-trimester ultrasound scan.
• •4. Participants who provided written informed consent for amniocentesis.
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