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Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure | Clinical Trials | Clareo Health

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Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome

NCT00471731•National Eye Institute (NEI)

Summary

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Detailed Description

Eligibility

Age

18 - No limit years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•1. Ability to understand and give informed consent.
•2. Meet the diagnostic criteria for TS (45, X0) or premature ovarian failure OR age matched control for study participant with TS or POF.
•3. For non Turner syndrome subjects only - Negative pregnancy test or post menopausal status for greater than or equal to 1 year.
•4. Karyotype of XO for TS subjects or XX for POF and age matched control subjects.

Exclusion Criteria

•1. Persons less than 18 years old.
•2. Persons with ophthalmic diseases associated with ocular surface disease.
•3. Hyperprolactinemia.
•4. Cushing s syndrome.
•5. Other endocrine disorders which impact sex steroid hormones.
•6. AIDS
•7. Pregnancy or lactation.
•8. For age matched control population ONLY- complaints of dry eye.
•9. For age matched control population ONLY- oral contraceptives or menopausal hormone therapy or any medications which alter sex hormone levels in the blood or chronic usage of medications that induce dry eye.

Locations (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, United States

Key Dates

Start Date

May 7, 2007

Completion Date

November 13, 2014

Last Updated

February 14, 2018

Enrollment

ACTUAL participants

Conditions

Turner SyndromeOvarian Failure, PrematureSex Chromosome AberrationsMenopausePerimenopause

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 14, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Inclusion Criteria

Exclusion Criteria

Natural History of Noncirrhotic Portal Hypertension

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