Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas

Inclusion Criteria

• •1. Adult ≥18 years of age
• •2. Have a diagnosis of NF1 based on germline genetic testing or by meeting ≥ 2 the following criteria:
• •1. Family history of NF1
• •2. Six or more light brown ("cafe-au-lait") spots on the skin
• •3. Presence of two or more neurofibromas of any type, or one or more plexiform neurofibromas
• •4. Freckling under the arms or in the groin area
• •5. Two or more pigmented, benign bumps on the eye's iris (Lisch nodules)
• •6. A distinctive bony lesion: dysplasia (abnormal growth) of the sphenoid bone behind the eye, or dysplasia of long bones, often in the lower leg
• •7. Tumor on the optic nerve that may interfere with vision
• •3. Patients must be seeking treatment for cNF
• •4. Patients must have ≥ 6 paired cNF (3 to be treated and 3 untreated) that are visible and measure between 2-8mm in size. These must be in areas amenable to treatment and surveillance with digital photography.
• •5. cNF must be located on the trunk, arms or legs of the patient
• •6. Able and willing to comply with all visit, treatment and evaluation schedules and requirements
• •7. Able to understand and provide written informed consent