Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Age ≥18 years old.
Both male and female sex.
Newly diagnosed patients with active mild and moderate ulcerative colitis according to American College of Gastroenterology (ACG) Clinical Guideline for diagnosing Ulcerative Colitis in Adults.26
Patients treated with 5-aminosalisylic acid (mesalamine).

Patients with severe ulcerative colitis.
Patients with colorectal cancer.
Patients on rectal or systemic steroids.
Patients on immunosuppressants or biological therapies.
Patients with previously failed treatment with sulphasalazine.
Patients with known allergy to study medications.
History of complete or partial colectomy.
Patients with significant liver disease (fibrosis, cirrhosis, NASH, NAFLD).
Patients with other inflammatory diseases.
Patients with thyroid diseases.
Patients with arrhythmia, ischemic heart disease, and heart failure.
Patients with diabetes.
Patients on antioxidants supplement (vitamin A, C, E), selenium, co-enzyme Q.
Patients on amlodipine, levothyroxine, low strength aspirin, warfarin, atorvastatin, insulin, oral hypoglycemic, chemotherapy (drug-drug interaction).

Alpha Lipoic Acid in Ulcerative Colitis