Lead Sponsor

Peking Union Medical College Hospital

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

No

•Aged 18-40 years
•Simple obese individuals with stable body weight in the last three months before enrollment (28.0kg/m2 ≤ BMI \<35.0kg/m2)
•Impaired fasting blood glucose: Within the last three months before enrollment, the venous fasting blood glucose was between 6.1 and 7.0 mmol/L, and the 2-hour postprandial blood glucose was\<7.8 mmol/L and the glycated hemoglobin (HbA1c) was \< 6.5%

•Diagnosed patients with diabetes or those who use hypoglycemic drugs
•Patients with concomitant hyperthyroidism or hypothyroidism, or those taking thyroxine tablets
•Those who apply glucocorticoids within 12 weeks
•Individuals with suspected renal dysfunction (female: serum creatinine ≥ 84 µ mol/L; male: serum creatinine ≥ 104 µ mol/L) or suspected liver dysfunction (elevated transaminase \>3 times normal or cirrhosis)
•Secondary obesity (such as thalamic diseases, pituitary diseases, Cushing's syndrome, etc.)
•Previous weight loss surgeries
•Pregnant or lactating individuals
•Individuals with confirmed mental illness or eating disorders
•Women with polycystic ovary syndrome
•Individuals who are allergic or intolerant to experimental products
•Lactose intolerant individuals
•Those who have taken probiotics and/or probiotic drugs or supplements within one month before enrollment
•Those who fail to use intervention agents according to the study protocol or have severely incomplete visit records

Related studies

NCT06894498 · Obesity and Obesity-related Medical Conditions, Weight Loss

NCT05124808 · Gestational Diabetes, Pregnancy, High Risk, and more

NCT07595549 · Obesity, Overweight and/or Obesity, and more

NCT06937086 · Ulcerative Colitis, Obesity or Overweight

NCT07284875 · Obesity, Overweight

The Effects of Aronia Melanocarpa Extract on Obese Individuals With Impaired Fasting Blood Glucose