A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)

Exclusion Criteria

• •Taking any supplements other than vitamin D, iron, vitamin B12, potassium, magnesium, calcium or those needed for a medical indication must be reviewed by PI. If patient is on a supplement (including curcumin, probiotic, omega3) they must stop these for 2 weeks prior to enrollment on study.
• •Patients that already follow a whole foods plant based diet (ovo-lactovegetarian or processed junk food vegan diets are not excluded). This will be per research dietitian evaluation and discretion after nutrition screening.
• •Legume allergy
• •Severe allergies such as anaphylactic shock to peanuts and/or tree nuts, such as cashews
• •Concurrent participation in weight loss/dietary trials or defined programs (that require specified diets/supplements on the program). Patients on weight loss drugs are eligible.
• •Mental impairment leading to inability to cooperate
• •Enrollment onto any other therapeutic investigational study
• •Concurrent pregnancy
• •Patients on full dose anticoagulation
• •If in the opinion of the investigator there maybe any concerns regarding the ability of the patient to complete the study safely
• •Current self-reported heavy alcohol use and is defined as \>5 drinks per day or \>15 drinks per week
• •Current self-reported illicit drug use (except inhaled marijuana, vaping or cigarette smoking or medical marijuana.
• •Has a condition requiring antibiotics within 14 days of study intervention administration.
• •Plan for travel during the study that would preclude adherence to prescribed diets
• •History of active inflammatory bowel disease or major gastrointestinal surgery (not including appendectomy or cholecystectomy) within 3 months of enrollment or any history of total colectomy, or bariatric surgery (bariatric surgery which does not disrupt the gastrointestinal lumen, i.e. restrictive procedures such as banding, are permitted)