Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback

Inclusion Criteria

• •Meets The Diagnostic and Statistical Manual of Mental Disorders five (DSM5) criteria for Major Depressive Disorder, single or recurrent, active or in partial remission
• •Patient Health Questionnaire (PHQ9) greater or equal (≥)6, and approximately (\~) 50% with PHQ9≥10
• •If participants are taking antidepressant medications, on stable dosage for 4 weeks
• •No history of active substance use disorder in the past 6 months
• •Absence of suicidal thoughts with plans or intentions, as assessed by Columbia Suicide Severity Rating Scale (C-SSRS)
• •If a woman of child-bearing age, not pregnant or trying to become pregnant
• •Ability to tolerate small, enclosed spaces without anxiety
• •No metals, implants or metallic substances within or on the body that might cause adverse effects to the subject in a strong magnetic field, or interfere with image acquisition, e. g. aneurysm clips, retained particles (for example metal workers with exposures, protocol has more details), etc.
• •Size compatible with scanner gantry (per protocol)
• •Ability and willingness to give informed consent to participate.