Age

0–2

Sex

ALL

Healthy volunteers

Not accepted

Infants less than 24 months old
Follow-up by a pneumo-pediatrician for severe asthma in infants
Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)
Parent informed of the research and having signed consent

Prematurity \<32 WA
Congenital heart disease with significant left to right shunt
Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)
Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)
Refusal of bronchial fibroscopy

Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma