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A Phase 2 Basket Study of Disitamab Vedotin in Adult Subjects With Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors That Express HER2
This clinical trial is studying advanced or metastatic solid tumors. Once a solid tumor has grown very large in one spot or has spread to other places in the body, it is called advanced or metastatic cancer. Participants in this study must have head and neck cancer, non-small cell lung cancer, endometrial cancer, or ovarian cancer. In the first part of the study, participants must have tumors that have a marker called HER2. This clinical trial uses an experimental drug called disitamab vedotin (DV). DV is a type of antibody-drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. In this study, all participants will get DV once every 2 weeks. This study is being done to see if DV works to treat different types of solid tumors that express HER2. It will also test how safe the drug is for participants. This trial will also study what side effects happen when participants get the drug. A side effect is anything a drug does to your body besides treating the disease.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Chandler, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Gilbert, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Glendale, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Mesa, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Mesa, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Phoenix, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Scottsdale, Arizona, United States
Valkyrie Clinical Trials(Additional Suite)
Los Angeles, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
University of California Davis Comprehenvise Cancer Center
Sacramento, California, United States
Start Date
November 14, 2023
Primary Completion Date
May 31, 2026
Completion Date
May 31, 2028
Last Updated
March 16, 2026
120
ACTUAL participants
disitamab vedotin
DRUG
Lead Sponsor
Seagen, a wholly owned subsidiary of Pfizer
NCT07213804
NCT06667908
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT04165798