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Unraveling the Klinefelter's Disease Physiopathology by Organoid Model
Organoid Model to unravel Klinefelter Syndrome infertility Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men. The investigators will isolate and expand spermatogonial cells from KS patients, then using an organoid model investigators will compare the behavior of these Spermatogonia from KS patients when interacting with four combinations of somatic cell types incorporated in the Extra Cellular Matrix hydrogel.
Men with Klinefelter Syndrome candidate for TESE or microTESE (testicular sperm extraction) for azoospermia. One extra testicular biopsy (1-2 mm) will be cryopreserved and used later for the cells isolation and culture.
Age
5 - 50 years
Sex
MALE
Healthy Volunteers
No
Cliniques Universitaires St Luc
Brussels, Belgium
Start Date
June 12, 2018
Primary Completion Date
April 1, 2025
Completion Date
April 1, 2025
Last Updated
August 18, 2023
20
ESTIMATED participants
Testicular biopsy
PROCEDURE
Lead Sponsor
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
NCT05903859
NCT05951075
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT06841861