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RECRUITINGPHASE3

Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)

NCT05903859•University of Miami

Summary

This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well. This study will determine if a medicine given by mouth will improve sperm motility in men with spinal cord injuries. The medicine is called probenecid.

Eligibility

Age

18 - No limit years

Sex

MALE

Healthy Volunteers

Inclusion Criteria

•1. Subject has a traumatic spinal cord injury.
•2. Subject is male and is 18 years or older.

Exclusion Criteria

•1. Subject has been injured less than 1 year.
•2. The subject is known to be azoospermic.
•3. The subject has an indwelling urethral Foley catheter.
•4. Subject is under the age of 18 years.
•5. Subject has an unstable medical condition including, but not limited to, Crohn's disease, ulcerative colitis, colon cancer or has other conditions deemed to be exclusionary per the Investigator.
•6. Subject is unable to consent or comprehend the procedures and their implications.
•7. Subject has a permanent implanted electrical device, i.e., cardiac pacemaker, phrenic nerve stimulator, spinal cord stimulator, etc.
•8. Any subject for whom the procedure or medication is otherwise contraindicated.
•9. Subject has hypersensitivity to probenecid.
•10. Subject has a history of uric acid kidney stones and/or peptic ulcer.
+3 more criteria

Locations (1)

University of Miami

Miami, Florida, United States

Key Dates

Start Date

January 18, 2024

Primary Completion Date

May 31, 2027

Completion Date

December 31, 2028

Last Updated

March 2, 2026

Enrollment

ESTIMATED participants

Conditions

Infertility, Male

Interventions

Probenecid 500 Milligrams (mg)

DRUG

probenecid 250 Milligrams (mg)

DRUG

Placebo

DRUG

Contacts

Odaro Ugbo, BSc

CONTACT

305-243-1491 oxu32@miami.edu

Orrey Padilla

CONTACT

305-243-1491 oxp210@med.miami.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 2, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)

Inclusion Criteria

Exclusion Criteria

Prospective Study on Power Prenatal Vitamins for Males on YO Score At-home Sperm Test Results

Spermatogonial Differentiation Via Testicular Organoid

Autologous Transplantation of Human Cryopreserved Testis Tissue

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Aromatherapy in Providing a Semen Sample

Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate