Clinical and Histological Evaluation of BTL-785F Non-invasive Treatment for Facial Rejuvenation

Exclusion Criteria

• •Bacterial or viral infection, acute inflammations
• •Impaired immune system
• •Isotretinoin in the past 12 months
• •Skin related autoimmune diseases
• •Radiation therapy and/or chemotherapy
• •Poor healing and unhealed wounds in the treatment area
• •Metal implants
• •Permanent implant in the treated area
• •Pacemaker or internal defibrillator, or any other active electrical implant anywhere in the body
• •Facial dermabrasion, facial resurfacing, or deep chemical peeling in the treatment area within 3 months prior to the treatment
• •Current or history of skin cancer, or current condition of any other type of cancer, or pre-malignant moles
• •History of any type of cancer
• •Active collagen diseases
• •Cardiovascular diseases (such as vascular diseases, peripheral arterial disease, thrombophlebitis and thrombosis)
• •Pregnancy/nursing or IVF procedure
• •History of bleeding coagulopathies, use of anticoagulants
• •Any active condition in the treatment area, such as sores, psoriasis, eczema, rash and rosacea
• •Any surgical procedure in the treatment area within the last three months or before complete healing
• •Poorly controlled endocrine disorders, such as diabetes
• •Acute neuralgia and neuropathy
• •Kidney or liver failure
• •Sensitivity disorders in the treatment area
• •Varicose veins, pronounced edemas
• •Prior use of dermal fillers, botulinum toxin, lasers, etc. therapies in the treated area that can influence the study results at the investigator discretion
• •Unwillingness/inability to not change their usual cosmetics and especially not to use anti-aging or anti-wrinkles products in the treated area during the duration of the study including the follow-up period
• •Any other disease or condition at the investigator discretion that may pose risk to the patient or compromise the study
• •Any disease or condition contradicting the skin tissue biopsy
• •Any disease or condition that may compromise the histologic observation at the pathologist discretion