2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles

Exclusion Criteria

• •1. Subjects must not have active localized or systemic infections.
• •2. Subjects must not have a compromised ability for wound healing, such as: malnutrition, steroid use, history of collagen vascular disease (e.g., lupus, scleroderma, history of keloid scar formation), atrophic dermatitis or immunologic abnormalities such as vitiligo.
• •3. Subjects must not have had treatments with 5FU, diclofenac, imiquimod, steroids, retinoids, or PDT within 1-month prior to enrollment.
• •4. Subjects must not currently be taking Accutane or have taken Accutane within the last 1-month.
• •5. Subjects must not have a known allergy to lidocaine or epinephrine, topical or injectable products containing lidocaine or any numbing medications.
• •6. Subjects must not have had previous surgery and/or fat transfer in the treatment area within the last 6-months.
• •7. Subject must not have had injectable soft tissue fillers within the last 12 months in the treatment area.
• •8. Subject must not have had Poly-L-Lactic acid (PLLA) fillers within the last 2 years in the treatment area.
• •9. Subject must not have had permanent filler i.e., Polymethylmethacrylate (PMMA) in the treatment area.
• •10. Subjects must not have had neurotoxins within the last 3-months in the treatment area.
• •11. Subject must not have a personal history of any facial threads i.e., PDO (Polydioxanone), PLLA (Polylactic acid), PCL (Polycaprolactone) in the treatment area within the last 12 months.
• •12. Subject must not have had a pulse dye or vascular laser, non-ablative laser, microneedling, or energy-based device treatment in the treatment area within the last 3 months.
• •13. Subject must not have had an ablative laser treatment in the treatment area within the last 6 months.
• •14. Subjects must not have a personal history of malignant melanoma, keloid scars, generalized psoriasis or systemic diseases that would preclude the use of topical anesthesia.
• •15. Subject must not have active sunburn or excessively tanned skin.
• •16. Subjects must not be pregnant or breastfeeding, think they may be pregnant or are trying to get pregnant during the study.