Requirement for new start of a biologic or small molecule during the hospitalization prior to randomization and/or anticipated requirement for rescue medical or surgical therapy within 48 hours of randomization
Toxic megacolon
Inability to receive intravenous steroids
Historically failed or been exposed to 4 or more classes of advanced therapeutic options
Known or suspected diagnosis of Crohn's colitis, indeterminate colitis, ischemic colitis, radiation colitis, diverticular disease associated with colitis, microscopic colitis or infectious colitis
Received any investigational drug within 30 days
Clinically significant cardiac, renal, neurological, endocrine, respiratory or hepatic impairment that increases the risk for HBOT toxicity
Women who are pregnant or nursing
Unwillingness to complete course of HBOT
Clareo Health | Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
