A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

Exclusion Criteria

• •have second- or third-degree atrioventricular (AV) heart block or AV dissociation or history of ventricular tachycardia
• •have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques)
• •have surgery planned during the study for any reason, related or not to the disease state under evaluation.
• •have, in the judgment of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation.
• •have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision.
• •have fibromyalgia
• •have substance use disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association)
• •have any clinically important abnormality at screening, as determined by investigator, in physical or neurological examination, vital signs, electrocardiogram (ECG), or clinical laboratory test results that could be detrimental to the participant or could compromise the study.
• •have a positive human immunodeficiency virus (HIV) test result at screening
• •have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2 years prior to screening.