Loading clinical trials...

Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity | Clinical Trials | Clareo Health

SUSPENDEDNA

Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity

NCT05956067•University of North Carolina, Chapel Hill

Summary

Participants with chronic pain conditions including chronic low back pain and fibromyalgia may benefit from light stimuli presented to the retina to reduce chronic pain severity and pain sensitivity. Participants will be recruited into this study and will be presented with one of three uniform light stimuli via a wide-field ganzfeld in three conditions to determine the retinal mechanisms that reduce pain. This work will lead to a greater understanding of retinal mechanisms that contribute to pain and will assist the design of future studies to harness the potential of light based pain therapies.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Adults greater than or equal to 18 and less than or equal to 65.
•Individuals who have been diagnosed with fibromyalgia or chronic low back pain by their physician.
•Individuals who experience an average pain severity greater than 4/10 in intensity at baseline.
•Willingness to wear a battery-operated portable ganzfeld light stimulator device for 2 hours per day at the same time each day (ideally complete the light therapy session between 5 am-10 am each morning) for 5 days.
•Alert and oriented, and able to provide informed consent
•Ability to read and speak English to complete validated questionnaires.

Exclusion Criteria

•Vision disorders or conditions resulting in severe vision impairment or blindness
•Individuals with self-report of color blindness
•Prisoner Status
•Pregnancy
•No other history or condition that would, in the investigator's judgment, indicate that the patient would very likely be non-compliant with the study or unsuitable for the study (e.g., might interfere with the study, confound interpretation, or endanger the patient).
•History of seizure disorder

Locations (1)

University Of North Carolina

Chapel Hill, North Carolina, United States

Key Dates

Start Date

August 25, 2023

Primary Completion Date

July 17, 2026

Completion Date

July 29, 2026

Last Updated

February 17, 2026

Enrollment

ESTIMATED participants

Conditions

Chronic Low-back PainChronic PainFibromyalgia

Interventions

Green Light stimulation

DEVICE

Equal Energy White stimulation

DEVICE

S-cone modulating white light

DEVICE

Optimization of NIBS for Treatment of Addiction

NCT04379115

Opioid-use DisorderChronic Pain

View study

RECRUITINGNA

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

NCT05508360

Degenerative Disc DiseaseChronic Low-back Pain

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 17, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity

Inclusion Criteria

Exclusion Criteria

Optimization of NIBS for Treatment of Addiction

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

VR Mindfulness Training for Veterans With SCI

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

The EXOPULSE Study - a Database for Routine Follow-up of Clinical Outcomes

Personalized High-Definition tDCS Protocols for Chronic Pain Treatment