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During cardiorenal syndrome type 1 (CRS1) vascular congestion is the major contributor to worsening renal function, but promoting decongestion with routine clinical evaluation is ineffective in some patients. The venous evaluation by ultrasound (VExUS) may optimize its management when evaluating for improvement in kidney function and other metrics related to decongestion.
Background: In cardiorenal syndrome type 1 (CRS1) vascular congestion is a common complication, the Venus Evaluation by Ultrasound System (VExUS) could guide decongestion effectively and thereby improve kidney function outcomes. Methods: In this double-blind randomized clinical trial, patients with CRS1 were randomized to guide decongestion with VExUS compared to usual clinical evaluation. The primary and secondary endpoint was to assess kidney function recovery (KFR), days of hospitalization, mortality, changes in brain natriuretic peptide (BNP) and CA-125. Protocol register HCG/CEI-0836/22.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
HCG
Guadalajara, Jalisco, Mexico
Start Date
March 20, 2022
Primary Completion Date
February 20, 2023
Completion Date
February 26, 2023
Last Updated
July 10, 2023
140
ACTUAL participants
Vexus
DIAGNOSTIC_TEST
Control group
OTHER
Lead Sponsor
Hospital Civil de Guadalajara
NCT05806645
NCT07472426
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT07447791