Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial

Exclusion Criteria

• •1. Undergoing cardiac surgery;
• •2. Undergoing intracranial neurosurgery;
• •3. Undergoing surgery for creation or revision of arteriovenous fistula or graft for dialysis access;
• •4. Planned use of prophylactic systemic TXA or ϵ-aminocaproic acid;
• •5. Hypersensitivity or known allergy to TXA;
• •6. History of seizure disorder;
• •7. Recent (within 90 days) stroke, myocardial infarction, acute arterial thrombosis, deep venous thrombosis, pulmonary embolism, or thrombosis of an arteriovenous fistula or graft;
• •8. History of thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, or antiphospholipid antibody syndrome;
• •9. Women who are known to be pregnant, breastfeeding, or who meet both of the following criteria: i) are of childbearing potential and do not have a negative pregnancy test documented in the 7 days before surgery, AND ii) are not using effective contraception; or
• •10. Previously enrolled in the BRACKETS-Pilot Trial.
• •Eligibility criteria specific to the desmopressin factorial component of trial
• •1. The hospital does not have access to desmopressin;
• •2. Planned use of prophylactic desmopressin;
• •3. Most recent serum sodium concentration \< 130 mEq/L;
• •4. Known or suspected von Willebrand disease (any kind), hemophilia, or platelet function disorder; or
• •5. Hypersensitivity or known allergy to desmopressin.