The main purpose of this study is to evaluate the systemic exposure to B17MP, FF, and GB as the area under the concentration-time curve from zero to time 't' where t is the last quantifiable time point (AUC0-t) and maximum plasma concentration (Cmax) across two different dose strengths of CHF 5993 BDP/FF/GB (200/6/12.5 μg and 100/6/12.5 μg).
The secondary purposes of the study are:
1. To evaluate the pharmacokinetic profile of BDP and additional pharmacokinetic parameters of B17MP, FF, and GB across two different dose strengths of CHF 5993 BDP/FF/GB (200/6/12.5 μg and 100/6/12.5 μg);
2. To compare the exposure to BDP and B17MP between the high dose BDP/FF/GB (total daily dose \[TDD\]: 800/24/50 µg) and the highest US-approved dose of QVAR (TDD 800 µg).
3. generate additional safety and tolerability information of the two CHF 5993 pDMI strengths, after a single dose.
Participation in the study will last for a maximum of 70 days for each subject (starting from randomization).
