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Active Not RecruitingNCT05800093

Proteomics and Genomics Combined With CT to Predict CVD

This study evaluates plaque progression and characteristics in patients with coronary atherosclerosis.

Lead sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Age

50 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Adult patients between 50 and 75 years old
•Subjects at intermediate to high risk for ASCVD
•Asymptomatic patients without cardiac chest pain
•Evidence of atherosclerosis on baseline CCTA

Exclusion Criteria

•Renal insufficiency, defined as eGFR \< 30 ml/min
•History of cardiovascular events (myocardial infarction, peripheral artery disease and ischemic stroke)
•Use of lipid lowering therapy other than statin, ezetimibe or bempedoic acid monotherapy
•Change in lipid lowering therapy in the last 6 months
•Use of more than two antihypertensive agents
•No coronary atherosclerosis at baseline imaging
•Active malignancy requiring treatment
•Atrial fibrillation
•Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
•Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 2, 2025Terms

Trial snapshot

StatusACTIVE_NOT_RECRUITING

Phase—

Enrollment310

Start dateJan 2023

Last updatedOct 2, 2025

Condition

Coronary Artery Disease Progression

Locations shown

Amsterdam UMC, location AMC

Amsterdam

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 2, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions