Prasugrel Or Ticagrelor De-escalation in NSTE-ACS

Exclusion Criteria

• •known hypersensitivity to ticagrelor or prasugrel
• •presence of contraindications for ticagrelor or prasugrel
• •current treatment with oral anticoagulant or chronic therapy with low-molecular-weight heparin
• •history of ischemic stroke or transient ischemic attack
• •history of intracranial hemorrhage
• •recent gastrointestinal bleeding (within 30 days)
• •history of moderate or severe hepatic impairment
• •history of major surgery or severe trauma (within 3 months)
• •patient required dialysis
• •concomitant therapy with strong CYP3A inhibitors (ketoconazole, itraconazole, voriconazole, telithromycin, clarithromycin, nefazadone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir) or strong CYP3A inducers (rifampicin, phenytoin, carbamazepine, dexamethasone, phenobarbital) within 14 days and during study treatment
• •body weight below 60 kg