Lead Sponsor

H. Lee Moffitt Cancer Center and Research Institute

Collaborators

Age

65 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age ≥65 years
•Lymphoma, leukemia, or myeloma with commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment
•Eastern Cooperative Oncology Group (ECOG) performance status 0-2
•Able to read and speak English fluently
•Capable of providing informed consent
•For optional, tele-supervised aerobic training procedure involving stationary bicycle delivery, participants must live within a 2-hour drive of Moffitt Cancer Center as determined via Google Maps.

•Regular engagement in Resistance training (2x/week targeting all major muscle groups)
•Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions
•Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).
•Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT using body weight
•Numeric pain rating scale of ≥ 7 out of 10
•Myopathic or rheumatologic disease that impacts physical function
•Cognitive, visual, or auditory limitations that preclude safe engagement in remotely-supervised resistance training sessions or independent aerobic exercise (as determined by patients' treating oncologists and specified in clinic notes outlining disease history).

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Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy