The Efficacy and Safety of Tenofovir Amibufenamide to Treat Low-level Viraemia After Entecavir Treatment

Exclusion Criteria

• •1. Female patients who are pregnant or breastfeeding or who plan to become pregnant during the study period.
• •2. Men and women of childbearing potential who are unwilling to use an "effective" method of contraception as defined in the protocol during the study period.
• •3. Co-infection with HAV HCV, HIV, HDV or HEV; or co-infection with autologous liver, metabolism-related fatty liver, or drug-induced liver injury.
• •4. Diagnosis of hepatocellular carcinoma by imaging (with evidence of hepatocellular carcinoma)
• •5. Patients who have received a solid organ or bone marrow transplant
• •6. History of malignancy within 5 years prior to screening, except for specific tumors cured by surgical resection (basal cell dermal skin cancer, etc.); patients evaluated for probable malignancy were ineligible.
• •7. Currently receiving treatment with immunomodulators (e.g., corticosteroids), investigational drugs, nephrotoxic drugs, or drugs capable of regulating renal excretion. Drugs that modulate renal excretion.
• •8. Renal, cardiovascular, pulmonary, or neurological disease that is considered severe by the investigator.
• •9. Severe bone disease (e.g., osteochondrosis, chronic osteomyelitis, osteogenesis imperfecta, chondromalacia) or multiple fractures.
• •10. Subjects receiving a contraindicated combination drug (subjects receiving a contraindicated drug require a minimum 30-day washout period) and known hypersensitivity reactions to study drugs, metabolites or formulation excipients.
• •11. Current alcohol or drug abuse that, in the investigator's judgment, may interfere with the subject's compliance with study requirements.
• •12. Any other clinical condition that, in the opinion of the investigator, would render the subject unsuitable for the study or unable to comply with the dosing requirements medical condition or prior treatment.
• •13. Prior or existing clinical liver failure (Child-Pugh score ≥ grade B).