Quantifying Disease Progression in LBSL

Inclusion Criteria

• •In order to be eligible to participate in this study, a subject must meet all of the following criteria:
• •Age \> 16 years
• •Definite diagnosis of LBSL confirmed by DARS2 mutation analysis.
• •Able to understand Dutch or English and provide informed consent.
• •No contra-indications for MRI of brain and spinal cord.
• •Subjects eligible to participate as healthy controls must meet all of the following criteria:
• •Willing to visit the hospital
• •16 years or older
• •Provision of written informed consent to participate in the study obtained from the participant
• •For the MRI controls:
• •\- No contra-indications for MRI of the brain and spinal cord
• •A potential subject (patient or healthy control) who meets any of the following criteria will be excluded from participation in this study:
• •Unable to visit the hospital for the follow-up visits
• •Co-existing neurological disease that can cause pyramidal tract signs making interpretation of acquired data difficult (for instance, multiple sclerosis, stroke, etc)