Home Exercise for Individuals with Neurodegenerative Disease

Inclusion Criteria

• •The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing.
• •The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis.
• •The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis.
• •For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia.
• •We will also include patients with other neurodegenerative diseases similar to these disorders as determined by chart review and clinical exam.
• •Healthy Volunteers
• •Able to stand for 30 seconds without upper extremity support
• •Ambulatory (including use of a cane or a walker)
• •Able to walk for 2 minutes