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COMPLETEDPhase 2NCT05747430

SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)

This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections. The study will be c...

Lead sponsor: iRenix Medical, Inc.•7 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

iRenix Medical, Inc.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Capable of giving informed consent
•2. Stated willingness to comply with all study procedures and availability for the duration of the study
•3. Male or female, ≥ 18 years of age and receiving intravitreal anti-VEGF injections in one or both eyes

Exclusion Criteria

•1. Current or past diagnosis of endophthalmitis
•2. Current diagnosis of uveitis
•3. Monocular patients (vision 20/100 or worse in one eye) who are receiving injections in the better seeing eye
•4. Current use of viscous lidocaine products for ocular anesthesia prior to IVT
•5. Currently receiving intravitreal steroid injections
•6. Concurrent participation in another clinical trial
•7. Females who are pregnant, planning to become pregnant or lactating

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 3, 2026Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2

Enrollment155

Start dateFeb 2023

Last updatedApr 3, 2026

Condition

Retinal Disease

Locations shown

Coastal Eye Surgeons, LLC

Greenwich, Connecticut

Mississippi Retina Associates

Madison, Mississippi

Erie Retina Research, LLC

Erie, Pennsylvania

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 3, 2026Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions