Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Colorado, Denver
Age
40–any
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
-age 40+ years;
resting blood pressure \<140/90 mmHg;
fasted blood glucose \<126 mg/dL;
testosterone ≥400 ng/dL;
sedentary to recreationally active;
nonsmokers;
healthy as determined by medical history, physical exam, blood and urine chemistries and resting and exercise ECG during a physician supervised graded exercise treadmill test OR recent diagnosis of non-metastatic prostate cancer with plans to undergo androgen deprivation therapy;
PSA \<4.00 ng/dL if in the non-cancer group;
Gleason Score ≤7 if in the prostate cancer group;
no use of medications that might influence cardiovascular function (e.g., antihypertensives, lipid-lowering medications);
willing and able to be on GnRHagonist and AR inhibitor;
not taking antioxidant vitamins, corticosteroids, or anti-inflammatory medications, or willing to stop use for four weeks prior to the start of the study;
not using exogenous sex hormones for at least one year
pre-existing or active cardiac, renal or hepatic disease, epilepsy or other seizure disorder;
diabetes, active or chronic infection, disease that affects the nervous system;
Gleason Score ≥8;
thyroid dysfunction, defined as ultrasensitive TSH \<0.5 or \>5.0 mU/L, volunteers with abnormal TSH values will be re-considered for participation after follow-up evaluation by the PCP with initiation or adjustment of thyroid hormone replacement;
