Contributions to Hypertension With Androgen Deprivation Therapy

Inclusion Criteria

• •-age 40+ years;
• •resting blood pressure \<140/90 mmHg;
• •fasted blood glucose \<126 mg/dL;
• •testosterone ≥400 ng/dL;
• •sedentary to recreationally active;
• •nonsmokers;
• •healthy as determined by medical history, physical exam, blood and urine chemistries and resting and exercise ECG during a physician supervised graded exercise treadmill test OR recent diagnosis of non-metastatic prostate cancer with plans to undergo androgen deprivation therapy;
• •PSA \<4.00 ng/dL if in the non-cancer group;
• •Gleason Score ≤7 if in the prostate cancer group;
• •no use of medications that might influence cardiovascular function (e.g., antihypertensives, lipid-lowering medications);
• •willing and able to be on GnRHagonist and AR inhibitor;
• •not taking antioxidant vitamins, corticosteroids, or anti-inflammatory medications, or willing to stop use for four weeks prior to the start of the study;
• •not using exogenous sex hormones for at least one year