Drug-Drug Interaction Study of Chiglitazar in Healthy Subjects.

Exclusion Criteria

• •History of clinically significant allergy or atopic allergic disease, or allergy to the study drug;
• •Previous surgery may affect drug absorption, distribution, metabolism and excretion; or have suffered from gastrointestinal, liver and kidney diseases that can affect drug absorption or metabolism in the past 6 months;
• •History of tuberculosis;
• •Frequent infection history in the past year, or serious infections leading to hospitalization within 3 months before administration;
• •untreated diarrhea, or diarrhea within 7 days before administration;
• •Any drugs, vitamin products or herbal medicine used within 1 month before administration;
• •History of drug abuse;
• •Participated in clinical trial within 3 months before administration;
• •Blood donation or massive blood loss within 3 months before the first administration;
• •Pregnant or lactating women;
• •Regular drinking history; or took any alcoholic products within 48 hours before administration; or positive alcohol test;
• •Regular smoking history within 3 months before administration or cannot quit smoking during the trial;
• •GFR\<80 mL/min;
• •Abnormal results of laboratory examination,vital signs, 12 lead ECG, physical examination and chest X-ray;
• •Systolic blood pressure\<90 or ≥ 140 mmHg, diastolic blood pressure\<60 or ≥ 90 mmHg;
• •Other situations that are not suitable for participate the study.