R-3750 in Patients With Mild to Moderate Ulcerative Colitis

Exclusion Criteria

• •Pregnancy, planned pregnancy, breastfeeding women
• •Evidence of severe UC disease (MMDAI score greater than or equal to 10)
• •Evidence of any active or recent infection including chronic infectious disease such as Hepatitis B, C, or HIV
• •Evidence of any active or recent chronic chest infection with bronchiectasis or sinusitis, or covid-19 infection in the past 3 months
• •Treatment with immunosuppressants or anti-cancer drugs, e.g., anti-TNF-α agents, anti-integrin agents, azathioprine or 6-MP, 6-thioguanine, methotrexate, ozanimod, tofacitinid, upadacitinib, tacrolimus, cyclophosphamide, or cyclosporine or any other therapy that is not an aminosalicylate within the last 3 months
• •Received an investigational drug within 3 months (or 5 half-lives, whichever is longer) before study entry
• •Use of steroidal drugs to treat UC (e.g., prednisone \>20 mg/day)
• •Use of probiotics within the last one (1) week and during the trial.
• •Treatment with systemic broad-spectrum antibiotics in the past 2 months
• •Major active systemic autoimmune disease other than UC
• •History of anaphylaxis or allergies to probiotics
• •History of alcohol or drug abuse within the past 2 years
• •History of stroke, or any cerebrovascular disease requiring medication/treatment
• •History of cancer, apart from successfully treated basal cell carcinoma or in situ carcinoma of the cervix \>1 year prior to enrollment
• •Significant laboratory abnormalities, including liver transaminases (AST or ALT) \> 1.5X the upper limit of normal.
• •Second degree or higher heart block or clinically significant arrythmia
• •Any other clinically significant renal, hepatic, hematological or other disease or laboratory abnormality which, in the opinion of the investigator, would interfere with the conduct, the interpretation of the safety signals or results of the trial, or would place the subject at unacceptable risk
• •Any condition or circumstance that, in the opinion of the Principal Investigator, would compromise the safety of the subject or the quality of study data