Clinical Outcomes of HBeAg-negative CHB Patients With Indeterminate Phase

Exclusion Criteria

• •1. Coinfection with hepatitis A virus, hepatitis C virus, hepatitis D virus, hepatitis E virus or human immunodeficiency virus;
• •2. Coexisting of hepatocellular carcinoma and other malignancy, or alpha-fetoprotein \>upper limit of normal at enrollment;
• •3. Presence of liver cirrhosis;
• •4. Alcohol abuse within the last year (ethanol: male \>40 g/d, female \>20 g/d; or heavy drinking within 2 weeks before enrollment: ethanol \>80 g/d), or history of drug abuse;
• •5. Participating in other clinical trials in the last 3 months;
• •6. Coexisting of autoimmune liver diseases;
• •7. Pregnant or planned pregnancy in a short term or lactation patients;
• •8. History of severe heart disease, mental disease;
• •9. Uncontrolled diabetes, hypertension, thyroid dysfunction, retinopathy, autoimmune diseases;
• •10. Neutrophil count \<2×10\^9/L and/or platelet count \<100×10\^9/L;
• •11. History of organ transplantation or preparing for organ transplantation;
• •12. Using immunosuppressive drugs;
• •13. Undergone organ transplantation or preparing for organ transplantation;
• •14. Receiving immunosuppressive agents;
• •15. Patients thought by the investigators not suitable to participate in this study.